SKU: 62980078430

PARP Mouse mAb

Sale price$172.80 Regular price$192.00
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Description

PARP Mouse mAbPoly [ADP ribose] polymerase 1 (PARP 1) also known as NAD+ ADP ribosyltransferase 1 or poly[ADP ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication,

Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.

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SKU: 62980078430

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4.1 ★★★★★
Based on 2017 reviews
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Jennifer S. Worley
Draper, US
★★★★★ 5
Tough little toy for super chewers.
Size: Shoes
Great my two Yorkies. Bought two. So far, still in one piece. UPDATE: This toy does not stand up to being washed. Since it is a "material" and not rubber, I would advise against buying it if you wash your dog toys. Sorry I bought several.
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Reviewed in the United States on December 1, 2025
V
Verified Purchase
Valentine's
Charlottesville, US
★★★★★ 1
Not a durable toy.
Size: Drop Ball, Size: Drop Ball
I was very disappointed in this rope toys. It took one day for my Border Collie to destroy it. The rope is not a durable material at all. I had a rope toy that was like this one several years ago, but it was much more durable. It lasted a couple of years. I think this one would be great for a small puppy, but not for an adult dog. Very disappointing!
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Reviewed in the United States on April 19, 2026
M
Verified Purchase
MLove
Los Angeles, US
★★★★★ 5
Fabulous play!
Size: Drop Ball
It is small for my 1 yr old girl boxer... my bad for not reading the product size details. The tug rope is great, but my rough boxer loved it too much and couldn't be trusted with it after much play. This toy opened the door for my purchasing tougher rope pull toys from the same brand.
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Reviewed in the United States on March 16, 2026
M
Verified Purchase
Mrs. Tarbox
Cuba, US
★★★★★ 4
Good
Size: Four Packs
My dog loves them but two out of four have come untied
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Reviewed in the United States on April 4, 2026
K
Verified Purchase
Kathy Spink
Massapequa, US
★★★★★ 5
Great tug toy.
Size: Drop Ball
Great!! tug toy. Both out dogs love it.
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Reviewed in the United States on March 25, 2026

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